教育经历
2003-09至2009-07,清华大学医学院生物医学工程专业,博士
1999-09至2003-07,清华大学热能工程系热能与动力工程专业,学士
工作经历
2012-04至今,中国科学院理化技术研究所,历任助理研究员、副研究员、研究员
2015-09至2016-12,美国哈佛大学医学院及其附属麻省总医院,访问学者
2010-06至2010-12,日本东北大学原子分子材料科学高等研究机构,研究助理
2009-06至2012-04,中国科学院半导体研究所,博士后
长期从事液态金属材料和微流控技术的生物医学应用研究:
1. 液态金属材料的生物医学应用,包括液态金属神经连接与修复技术,柔性电子与电子皮肤等;
2. 微流控芯片与器官芯片技术,通过模拟体内环境构建仿生平台,研究环境、细胞、药物之间的相互作用;
3. 微流体技术与液态金属材料、微纳加工技术、组织工程学等的跨学科研究。
1. 国家重点实验室项目,液态金属冷冻凝胶导管修复外周神经损伤的研究;
2. 国家级项目,多通道液态金属柔性神经电极研发;
3. 国家重点实验室项目,仿生纳米针尖制造及其抗菌机理研究;
4. 国自然面上项目,多层液滴微流控芯片提高微生物可培养性的研究;
5. 国自然面上项目,量子点结合微流控芯片识别循环肿瘤细胞的光学检测方法研究;
6. 中科院重点部署项目,微流控芯片技术检测循环肿瘤细胞在肺癌中的应用研究;
7. 北京市教委,基于微流体技术的体外血管系统构建;
8. 所级项目,小口径人工血管构建关键技术探索。
[1] 桂林,高猛,叶子,李雷,液态金属微流体学,上海科学技术出版社,2021。
[2] Huan Hu and Lei Li, Micro/nanofabrication of IVD/POCT Biosensors, Bentham Science Publishers, Frontiers in Nanobiotechnology Vol. 1, 2020.
目前,已发表期刊论文50余篇,以第一或通讯作者在Bioactive Materials,Science Bulletin,Biosensors and Bioelectronics等国内外知名SCI期刊发表论文30余篇(影响因子大于10的论文5篇,中科院1区TOP期刊论文7篇)。
[1] Xiao Sun, Xiaohong Wang, Bingjie Wu, Qianhong Yang, Congxiao Zhu, Huimin Zhang, Qian Li, Hongru Zhou, Minghui Guo, Lin Gui*, Lei Li*. A biomimetic 3D magnetically responsive scaffold with tunable and stable compression for dynamic 3D cell culture. Science China-Materials, 2025, 68, 652.
[2] Xiao Sun, Zhenming Li, Chunwei Li , Huimin Zhang, Wei Liu, Mingyang Liu, Lei Li*, Lin Gui*. Hydrophilic hard-magnetic soft robots: a new approach for precise droplet manipulation. Nanotechnology and Precision Engineering, 2025, 8, 043012. (Nature亮点报道)
[3] Congxiao Zhu, Zonglin Huang, Hongru Zhou, Xuefeng Han, Lei Li*, Ningbei Yin*. Purified adipose tissue-derived extracellular vesicles facilitate adipose organoid vascularization through coordinating adipogenesis and angiogenesis. Biofabrication, 2025, 17, 025014.
[4] Siyuan Zhou, Lei Li*, Jianhua Cao, Xiubin Yang, Dayong Wu*. Transition from Procoagulation to Antiplatelet Effect: Applicationand Mechanism of Aspirin-Modified Chitosan in Small-DiameterVascular Grafts. ACS Applied Bio Materails, 2024, 8, 763.
[5] Xilong Zhang, Zhongshan Deng*, Huize Song, Minghui Guo and Lei Li*. Liquid Metal Electromagnetic Wave Shielding and Absorbing (EWSA) Film for Solving Electromagnetic Interference in Flexible Sensor Devices. Science China-Materials, 2024, 67, 3976.
[6] Xilong Zhang, Chang Liu, Rongyu Tang, Weichen Feng, Jingru Gao, Bingjie Wu, Zhongshan Deng, Jing Liu*, Lei Li*. Liquid metal neuro-electrical interface, Soft Sci, 2024, 4, 23. (Invited review)
[7] Sicong Liu, Lei Li*, Chanyuan Jiang, Qianyu Wang, Zhongshan Deng*. Synergistic injection of the thermosensitive hydrogel and bismuth-based alloy bone cement for orthopaedic repair. Science China-Technological Sciences, 2024, 67, 2153.
[8] Qingyue Guo,Lei Li*, Guanyue Gao, Qi Zhao, Xia Huang, Hao Wang, Bingxin Liu, Jinfang Zhi*. Nanodiamonds inhibit the proliferation and migration of endothelial cells in a tumor/endothelial cells co-culture microfluidic system. Carbon, 2024, 218, 118671.
[9] Siyuan Zhou, Lei Li*, Enzehua Xie, Meixi Li, Jianhua Cao, Xiubin Yang*, Dayong Wu*. Small-diameter PCL/PU Vascular Graft Modified with Heparin-aspirin Compound for Preventing the Occurrence of Acute Thrombosis. International Journal of Biological Macromolecules, 2023, 249, 126058.
[10] Xilong Zhang, Lei Li*, Zhongshan Deng*. Liquid Metal-Based Flexible Bioelectrodes for Management of In-Stent-Restenosis: Potential Application. Biosensors, 2023, 13(8), 795.
2014 中国制冷学会技术发明奖一等奖
2013 中国科学院科技成果在北京转化先进团队特等奖
2005 国际生物医学工程联合会杰出中国学生奖(全中国共6名)
人才队伍